Em Cirurgia Oral, Estomatologia

Luis Pagotto, et al.
Brazilian Journal of Oral and Maxillofacial Surgery
V.9, n.2, p.23-32, abr./jun.2009
Impact Factor: Qualis Capes: B Nacional


Fibrous dysplasia is a benign fibrous osseous lesion that may involve on or more bones of the skeleton, the maxilla being the facial bone most frequently involved. It is a sporadic condition that results form a post- zygotic mutation in the GNAS1 gene, a protein linked to the guanine nucleotide, α stimulant of polypeptide 1 activity. Its main histopathologic feature is the replacement of normal bone tissue and medullar tissue by fibrocellular tissue and immature bone. This paper presents two cases of monostotic fibrous dysplasia involving the maxilla and zygomatic bone, describing and discussing the clinical, radiological and histopa- thologic characterisitics, the differential diagnosis and treatment.

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